Tartaric Acid
Medchemexpress LLC ENMD-2076 Tartrate | 1453868-32-0 | 99.7% | 525.56 | 10 MG
ENMD-2076 Tartrate is a multi-targeted kinase inhibitor with IC50s of 1.86, 14, 58.2, 15.9, 92.7, 70.8, 56.4 nM for Aurora A, Flt3, KDR/VEGFR2, Flt4/VEGFR3, FGFR1, FGFR2, Src, PDGFRα, respectively. It is for research use only and not sold to patients.
- Acts as a multi-targeted kinase inhibitor
- Inhibits Aurora A, Flt3, KDR/VEGFR2, Flt4/VEGFR3, FGFR1, FGFR2, Src, and PDGFRα
- Shows selective inhibition of Aurora A over Aurora B
- Inhibits human umbilical vein endothelial cell (HUVEC) growth
- Blocks cellular Flt3 ligand (FL)-induced Flt3 autophosphorylation
- Prevents stem cell factor (SCF)-induced Kit autophosphorylation
- Inhibits VEGFR2/KDR autophosphorylation
- Demonstrates dose-dependent inhibition of tumor growth or tumor regression in vivo
- Exhibits good tolerance in daily doses during in vivo studies
Medchemexpress LLC ENMD-2076 | 934353-76-1 | 99.99% | 375.47 | 100 MG
ENMD-2076 is a multi-targeted kinase inhibitor with high selectivity towards Aurora A versus Aurora B. It inhibits HUVEC growth and shows antiproliferative effects on human leukemia cell lines. This compound induces G2-M-phase arrest and apoptosis in U937 cells and inhibits Flt3 and Kit autophosphorylation. In vivo, ENMD-2076 demonstrates dose-dependent inhibition of tumor growth and is well tolerated in animal studies.
- Multi-targeted kinase inhibitor.
- Inhibits HUVEC growth.
- Shows antiproliferative effects on leukemia cell lines.
- Induces G2-M-phase arrest and apoptosis.
- Inhibits Flt3 ligand (FL)-induced Flt3 autophosphorylation.
- Inhibits stem cell factor (SCF)-induced Kit autophosphorylation.
- Inhibits VEGFR2/KDR autophosphorylation.
- Results in dose-dependent inhibition of tumor growth in vivo.
![Alkali Scientific L (+) Tartaric Acid [(2R, 3R) (+) Tartaric acid/ L Threaric acid], 5 Kg](https://assets.fishersci.com/TFS-Assets/CCG/product-images/5000660100.jpg-250.jpg)
Alkali Scientific L (+) Tartaric Acid [(2R, 3R) (+) Tartaric acid/ L Threaric acid], 5 Kg
L (+) Tartaric Acid, ACS Grade, is a high-purity organic acid available in a 5 kg quantity. This chiral compound is essential for laboratory applications involving asymmetric synthesis and the production of optically active molecules. L (+) Tartaric acid is commonly used in the pharmaceutical and chemical industries for creating enantiomerically pure compounds, and it is an important reagent in biochemistry, organic chemistry, and analytical chemistry. This tartaric acid grade is ideal for use in optical isomer studies and in the development of various products, ensuring high purity and reliable results in laboratory experiments.
Selleck Chemical LLC Tartaric acid S2997-100mg
Tartaric acid (2 3-Dihydroxysuccinic acid) is a white crystalline organic acid isolated from many plants particularly tamarinds and grapes and is used as an antioxidant and an additive agent to give a sour taste
Selleck Chemical LLC ENMD-2076 S1181-10mM/1mL
ENMD-2076 has selective activity against Aurora A and Flt3 with IC50 of 14 nM and 1 86 nM 25-fold selective for Aurora A than over Aurora B and less potent to RET SRC NTRK1/TRKA CSF1R/FMS VEGFR2/KDR FGFR and PDGFR ENMD-2076 inhibits the growth of a wide range of human solid tumor and hematopoietic cancer cell lines with IC50 from 0 025 to 0 7 M which induces apoptosis and G2/M phase arrest Phase 2
Apexbio Technology LLC ENMD-2076 934353-76-1 200mg
ENMD-2076 (CAS 934353-76-1) is a selective inhibitor of Aurora A kinase (IC50 14 nM) and FLT3 (IC50 1 86 nM) with additional inhibitory activity against multiple tyrosine kinases implicated in angiogenesis and cell proliferation including RET FLT4/VEGFR3 SRC CSF1R NTRK1 FGFR1/2 VEGFR2/KDR LCK and PDGFR (IC50 1 86 120 nM) ENMD-2076 disrupts cell cycle progression by arresting cells in the G2/M phase through inhibition of Aurora kinases suppresses the PI3K/AKT signaling pathway and demonstrates cytotoxic effects in hematologic malignancy and solid tumor cell lines (in vitro IC50 25 700 nM) In vivo it reduces tumor growth and angiogenesis in xenograft models supporting its use in cancer research and antiangiogenic studies
Apexbio Technology LLC ENMD-2076 934353-76-1 5mg
ENMD-2076 (CAS 934353-76-1) is a selective inhibitor of Aurora A kinase (IC50 14 nM) and FLT3 (IC50 1 86 nM) with additional inhibitory activity against multiple tyrosine kinases implicated in angiogenesis and cell proliferation including RET FLT4/VEGFR3 SRC CSF1R NTRK1 FGFR1/2 VEGFR2/KDR LCK and PDGFR (IC50 1 86 120 nM) ENMD-2076 disrupts cell cycle progression by arresting cells in the G2/M phase through inhibition of Aurora kinases suppresses the PI3K/AKT signaling pathway and demonstrates cytotoxic effects in hematologic malignancy and solid tumor cell lines (in vitro IC50 25 700 nM) In vivo it reduces tumor growth and angiogenesis in xenograft models supporting its use in cancer research and antiangiogenic studies
Chem-Impex International, Inc. (-)-Dibenzoyl-L-tartaric acid | MFCD00003074 | 1KG
(-)-Dibenzoyl-L-tartaric acid, MFCD00003074, 1KG
Medchemexpress LLC Inosinic acid disodi 50mg | 352195-40-5 | 50MG
Inosinic acid (disodium)(hydrate)(1 2 X) (5 -IMP (disodium)(hydrate)(1 2 X)) is an endogenous metabolite Inosinic acid (disodium)(hydrate)(1 2 X) is used as umami tastant or as the dietary supplement to improve the yield and meat quality of pigs[1
Selleck Chemical LLC ENMD-2076 L-()-Tartaric acid S2018-5mg
ENMD-2076 L-( )-Tartaric acid is the tartaric acid of ENMD-2076 selective activity against Aurora A and Flt3 with IC50 of 14 nM and 1 86 nM 25-fold more selective for Aurora A than Aurora B and less potent to VEGFR2/KDR and VEGFR3 FGFR1 and FGFR2 and PDGFR Phase 2